WebApr 7, 2024 · The recommended dose of thiotepa for injection for treatment of superficial papillary carcinoma of the urinary bladder is 60 mg in 30 to 60 mL of Sodium Chloride Injection into the bladder by catheter. ( 2.1) DOSAGE FORMS AND STRENGTHS. For injection: 15 mg, lyophilized white powder in single-dose vial for reconstitution. WebSep 12, 2024 · Thiotepa (thye' oh tep' a) is an ethylenimine similar in structure and activity to altretamine and is believed to act as an alkylating agent. The alkylating agents act by causing modification and cross linking …
Thiotepa - NCI - National Cancer Institute
WebJul 16, 2024 · About: Thiotepa (Thioplex®, Tepadina®) Thiotepa damages cancer cells through a process called alkylation. Alkylation damages the DNA of cells, which prevents … WebDec 6, 2014 · TBC consists of thiotepa 250 mg/ m 2 on day -9 to day -7, busulfan 3.2 mg/kg on day -6 to day-4 and cyclophosphamide 60 mg/kg on day -3 to day -2. BuCyE consists of busulfan 3.2 mg/kg on day -7 to day -5, etoposide 200 mg/m 2 twice a day on day -5 to day-4 and cyclophosphamide 50 mg/kg on day -3 and day -2. blythe church
A comprehensive understanding of thioTEPA metabolism …
WebThiotepa, a highly lipophilic, alkylating agent, and/or its active metabolites may be excreted in part via skin in patients receiving high-dose therapy. We present a case of cutaneous toxicity observed in a 4.5-year-old girl patient with medulloblastoma treated with a high-dose thiotepa conditioning regimen before autologous stem cell ... Webthiotepa is rapid and is followed by fast elimina-tion from the plasma compartment, with a half-life of 1–3 hours. Triethylenephosphoramide (TEPA), a metabolite of thiotepa, is … WebFeb 17, 2024 · Boxed Warning. Myelosuppression: Thiotepa may cause severe marrow suppression, and high doses may cause marrow ablation with resulting infection or bleeding. Monitor hematologic laboratory parameters. Hematopoietic progenitor (stem) cell transplantation is required to prevent potentially fatal complications of the prolonged … blythe clan tartan