Nettet15. nov. 2003 · Trauma in the adult mammalian central nervous system (CNS) has devastating clinical consequences due to the failure of injured axons to spontaneously … NettetThis review summarizes experiments aimed at answering the following questions: (i) is myelin-associated glycoprotein involved in the formation and maintenance of myelin in …
Axon Regeneration in Young Adult Mice Lacking Nogo-A/B
NettetTrembler mouse, particularly the minimal or abnormal mye- lination and reduced axonal diameter, make it a very attractive model to define the mechanisms by which defective peripheral myelination can modify axonal properties. We have compared slow axonal transport and regeneration of peripheral axons in Trembler and normal mice. Nettet17. sep. 2008 · These results show that granulocytes and monocytes/macrophages directly influence axon regeneration by regulating the balance between inhibitory molecules and growth … github 2921 ns2
Lack of evidence that myelin-associated glycoprotein is a major ...
NettetA/B /, and nogo-A/B mice. Myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) were used as control myelin proteins. (E) Anti-Nogo-A/B immunoblot in brain and lung lysates from nogo-A/B / /, nogo-A/B, and nogo-A/B mice. Note the clear Nogo-B band in wild-type lung that is absent from the homozygous mutant mouse … NettetAxon regeneration has three phases: sprouting, elongation, and maturation ( McQuarrie, 1983 ). As Schwann cells dedifferentiate and proliferate, the proximal stumps of the axons sprout by the actin-driven formation of growth cones (Sinicropi and McIlwain, 1987). Recent studies indicate that oligodendrocyte regeneration from endogenous progenitors is sufficient to restore myelin levels in layer I after demyelination; however, the pattern of myelin along individual axons is altered after remyelination, with a large fraction of sheaths established on previously … Se mer To define the pattern of myelination along axons of different subtypes of neurons in the cerebral cortex, we used Cre-lox and viral expression strategies to fluorescently label seven neuronal subpopulations that extend axon collaterals … Se mer The density of myelin varies considerably across the cortical mantle (Fig. 1b), with boundaries between cortical areas defined by their distinct … Se mer The relationship between axonal diameter and myelination has been thoroughly described in the context of peripheral nerves, CNS white matter, and even primary cell culture12,13,14,15,16,17,50, establishing that the … Se mer github 24/7